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The University of Exeter is a public research university in the West Country of England, with its main campus in Exeter, Devon. Its predecessor institutions, St Luke's College, Exeter School of Science, Exeter School of Art, and the Camborne School of Mines were established in 1838, 1855, 1863, and 1888 respectively. These institutions formed the University of Exeter when it received its royal charter in 1955. In post-nominals, the University of Exeter is abbreviated as Exon. ; this is the suffix given to honorary and academic degrees from the university.
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This PhD aims to understand why genetic liability to severe mental illness (SMI), particularly schizophrenia and bipolar disorder, is associated with different patterns of adiposity and metabolic health. Although obesity and type 2 diabetes (T2D) are more common in people with SMI, substantial…
Context/background Before the instructions in a gene can be used, non-coding parts called introns must be cut out in a process called splicing. Most introns are spliced out by the major spliceosome. However, around 700 human genes contain a rare type of intron (U12 introns) that can only be removed…
Context: Genome sequencing is becoming increasingly widespread in both research and diagnostics, and over a million people have already had their genomes sequenced. However, interpreting the effect of genetic variants is challenging and frequently delays diagnosis in patients with rare genetic…
Large-scale sequencing initiatives have identified thousands of genetic variants associated with human traits and disease. However, understanding how these variants influence biology remains a major challenge because genes do not act independently but within interconnected networks. Existing…
Alzheimer’s disease (AD) is characterised by distinctive molecular changes across multiple cell types in the human brain. Epigenome-wide association studies (EWAS) have identified widespread alterations in epigenetic modifications associated with AD pathology, but a major challenge remains: which…
The human brain contains an extraordinary diversity of cell types, each with distinct functions, molecular programmes and roles in disease. Even within neurons, numerous excitatory and inhibitory subtypes differ across brain regions and change across development and ageing. Understanding this…
Background Chromatinopathies is a group of more than 180 rare genetic disorders caused by variants in genes encoding chromatin remodelling factors . Collectively, these disorders are amongst the most prevalent genetic conditions and are often characterised by neurodevelopmental features including…
Type 2 diabetes (T2D) affects over 800 million people worldwide. It is a complex disorder and an individual’s genetics influences disease risk. Understanding how DNA differences drive this risk can enable disease prediction and personalised approaches to diagnosis and treatment, addressing the…
Alternative splicing enables a single gene to produce multiple mRNA isoforms, and potentially proteins with distinct functions. It is especially important in the brain, where transcript diversity supports development and ageing. Studies have implicated disrupted RNA splicing in neurodevelopmental,…
The discovery of quasicrystals – honoured with the 2011 Chemistry Nobel prize – has generated and continues to stimulate a tremendous amount of research in the international mathematics and physics communities. Questions concerning the characterisation of order versus disorder, diffraction and…
Around a third of children with epilepsy continue to have seizures despite medication. For those who cannot be helped by conventional surgery, electrical stimulation delivered by an implanted device is one of the few remaining options. Its use is expanding quickly, yet responses vary widely between…
Osteoporosis is a bone-wasting disease that makes bones thin, weak and more likely to break. Breaking bones in the hip and spine is painful and life-changing. It affects more women (1 in 2) than men (1 in 5) because women have smaller bones, lose bone-protecting hormones after the menopause and…
The study of L-functions — their moments, zero statistics, and connections to random matrix theory — sits at the heart of modern analytic number theory. Function fields over finite fields 𝔽_q provide a setting where deep conjectures first posed for classical L-functions become rigorously…
Digital Movement Biomarkers of Mood and Fatigue in Older Adults: Using Computer Vision, Artificial Intelligence and Functional Movement Analysis to Detect Anxiety, Depression and Fatigue in People with and without Multiple Long-Term Conditions (MLTCs) Depression, anxiety and fatigue are among the…
Falls are the most common cause of injury-related hospital admission and death among older adults, yet fall prevention has made little measurable progress for two decades. Around a third of people aged 65 and over fall each year, and falls result in around 210,000 emergency hospital admissions a…
Introduction Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder marked by inattention, hyperactivity, and impulsivity. Globally, it affects about 5% of children, with 30–50% continuing to experience symptoms into adulthood, leading to challenges in education,…
Self-organised systems in animals, such as the nests of social insects, have evolved to offer advantages that support survival across diverse habitats and climates. These nests represent ideal systems to study materials and their role in dynamic physical and biological processes. This PhD project…
Emotions and mood states are notoriously difficult to study in non-human animals, but recent years have seen important progress in inferring these states and their links to behaviour and welfare. For example, the use of judgment-bias tasks has shown that differences in housing conditions for…
Understanding how the ocean is changing requires observations that are increasingly extensive in both space and time. However, conventional oceanographic observations rely on relatively expensive and specialised instruments deployed from research vessels, autonomous platforms or fixed observing…
About The Role Postdoctoral Research Associate / Fellow This NERC funded full-time post is available from 1 April 2027 till 30 September 2028. The starting salary will be from £35,302 on Grade E for the Postdoctoral Research Associate level and from £44,352 on Grade F for the Postdoctoral…
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