Clinical Research FellowNHS

Job summary

The post holder will be responsible for oversight and delegated medical tasks for commercial clinical research trials within the Commercial Trials Team and NIHR Commercial Research Delivery Centre at Guy's and St Thomas . The primary focus will be two flu prevention trials. This will involve the use of a novel and advanced drugs and devices. You will work as part of and be supported by a multi-disciplinary research team with a strong track record of producing high quality research outcomes.

The post will be based at St Thomas Hospital, in the Clinical Research Facility and will include work at the phase 1 MHRA accredited Clinical Research Facility. However, it is a requirement that you be prepared to work at any additional or different location owned or served by the Trust, either on an on-going or temporary basis according to the demands of the service.

This post may close early if a sufficient number of applications have been received.

Main duties of the job

You will coordinate and lead research projects as a sub-investigator, recruit and follow up patients according to trial protocols, collect and analyse clinical data, maintain trial documentation, and contribute to publications and presentations. The role also includes participation in specialist clinics and close collaboration with principal investigators and wider research teams. You will be responsible for over seeing the delivery of clinical trial IMP and for the safety of participants recruited to trials.

Job description

As the Research physician, the post holder will:

Support the timely delivery of clinical studies to acceptable medical standards, in-line with the requirements of sponsors, ICH GCP, and other appropriate guidelines and regulations. Provide medical assessment and cover for selected early and late phase studies in the CTT, CRF and CRDC working alongside the senior clinical team, the research delivery team and the nurse in charge; In partnership with the CRF Physician and clinical staff, initiate definitive strategies to anticipate and expertly manage medical safety issues, including emergencies; Support aspects of subject recruitment, including pre-study medical histories, informed consent, medical examinations for ongoing studies, dosing of study medication; On a rota basis, provide medical cover outside of normal working hours, as determined by the nature of the studies being undertaken at the time; This can include twilight and night shift cover. Accept delegated responsibility to ensure that assigned studies are carried out safely and in compliance with the protocol; Be responsible for specific study-related medical decisions as agreed with the Study Principal Investigator; Perform clinical procedures as appropriate to the assigned study (including, but not limited to, clinical examinations or testing, insertion of intravenous lines, assessment of adverse events and management of medical emergencies); Ensure that patients/volunteers in assigned studies give fully informed consent in writing before commencing a study; Assess the eligibility status of referrals for experimental treatments, maintain and update a screening list. Evaluate and manage acute, sub-acute and chronic adverse drug reactions and manage acute toxicological emergencies under the supervision of the consultants or CRF physician in charge. Assess and interpret safety and clinical data from assigned studies, e.g. Vital signs, ECG's, laboratory tests, adverse events etc; Follow up and report adverse events as necessary. Communicate safety issues to the Principal Investigator for a study, the Head of Department or Designee, report Serious Adverse Events to the study sponsor in accordance with Good Clinical Practice; Review study documentation and complete appropriate sections of Case Report Forms; Ensure that all clinical activities within the CRF are conducted in accordance with approved Standard Operating Procedures (SOPs) Maintain accurate and accessible research records and medical notes; Provide medical input into integrated clinical, safety and statistical reports as requested; Contribute to the risk assessment and planning of risk mitigation strategies for early phase trials; Ensure personal Trust mandatory training is up to date and support the training of medical, nursing and ancillary staff as required; Any other duties as may be deemed reasonable by the CRDC leadership; Participation is expected in clinical, research delivery activities, governance and other service activities with the object of ensuring a high standard of patient care, including some overnight weekday resident responsibilities on a rotational basis.

About us

The commercial clinical trials team is a department within R&D that supports the accelerated discovery of novel approaches to the prevention, diagnosis and therapy of major diseases relevant to the NHS and will ultimately contribute to the improvement of patient outcomes. The team support researchers across Clinical Groups at GSTFT to deliver on their research agendas by providing an expert clinical trial delivery service, from study set-up through to close-down. The service is cross-speciality and will support the activities of the NIHR South London Commercial Research Delivery Centre (CRDC). This role will primarily focus on the delivery of two large flu prevention trials being delivered over the Autumn and Winter months

The team will deliver research visits both within the dedicated clinical trial facility, the phase 1 accredited Clinical research Facility at Guys Hospital and will actively support the activities of the NIHR South London CRDC .

This role provides an excellent opportunity to gain experience in clinical trial delivery alongside experienced research teams. We would need prospective candidates to be able to start as soon as possible for trials that begin in October and November 2026